Christiansen Grammar for Some P Systems

The main goal of this work is to formally describe P systems. This is a necessary step to subsequently apply Christiansen grammar evolution (an evolutionary tool developed by the authors) for automatic designing of P systems. Their complex structure suggests us two decisions: to restrict our study to a subset of P systems that ease the representation while keeping a suitable complexity and to select a powerful enough formal tool. Our work is restricted to a kind of P system that can simulate any logical function by means of delay symbols and two mobile catalysts. Like in general P systems, some components of these "logical" P systems depend on other components (for example, the number of axioms and regions and the set of possible indexes for the symbols in their rules depend on the membrane structure). So, a formal representation able to handle context dependent constructions is needed. Our work uses Christiansen grammars to describe P systems

The role of keeping "semantic blocks" invariant: effects in linear genetic programming performance

This paper is focused on two different approaches (previously proposed by the authors) that perform better than Genetic Programming in typical symbolic regression problems: straight-line program genetic programming (SLP-GP) and evolution with attribute grammars (AGE). Both approaches have different characteristics. One of themost important is that SLP-GP keeps semantic blocks invariant (the crossover operator always exchanges complete subexpressions). In this paper we compare both methods and study the possible effect on their performance of keeping these blocks invariant.This work was partially supported by the R&D program of the Community of Madrid (S2009/TIC-1650, project “e-Madrid”) as well as by the Spanish Ministry of Science and Innovation (TIN2007-67466-C02-02). The authors thank Dr. Manuel Alfonseca for his help to prepare this document

Developing Tools for Networks of Processors

A great deal of research eort is currently being made in the realm of so called natural computing. Natural computing mainly focuses on the denition, formal description, analysis, simulation and programming of new models of computation (usually with the same expressive power as Turing Machines) inspired by Nature, which makes them particularly suitable for the simulation of complex systems.Some of the best known natural computers are Lindenmayer systems (Lsystems, a kind of grammar with parallel derivation), cellular automata, DNA computing, genetic and evolutionary algorithms, multi agent systems, arti- cial neural networks, P-systems (computation inspired by membranes) and NEPs (or networks of evolutionary processors). This chapter is devoted to this last model

Automatic composition of music by means of Grammatical Evolution

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in APL Quote Quad, http://dx.doi.org/10.1145/604444.602249Proceedings of the 2002 conference on APL: array processing languages: lore, problems, and applications (Madrid)This work describes how grammatical evolution may be applied to the domain of automatic composition. Our goal is to test this technique as an alternate tool for automatic composition. The AP440 auxiliary processor will be used to play music, thus we shall use a grammar that generates AP440 melodies. Grammar evolution will use fitness functions defined from several well-known single melodies to automatically generate AP440 compositions that are expected to sound like those composed by human musicians.This paper has been sponsored by the Spanish Interdepartmental Commission of Science and Technology (CICYT), project numbers TEL1999-0181 and TIC2001-0685-C02-1

Recommendations for ophthalmologic practice during the easing of COVID-19 control measures

In the context of the COVID-19 pandemic, this paper provides recommendations for medical eye care during the easing of control measures after lockdown. The guidelines presented are based on a literature review and consensus among all Spanish Ophthalmology Societies regarding protection measures recommended for the ophthalmologic care of patients with or without confirmed COVID-19 in outpatient, inpatient, emergency and surgery settings. We recommend that all measures be adapted to the circumstances and availability of personal protective equipment at each centre and also highlight the need to periodically update recommendations as we may need to readopt more restrictive measures depending on the local epidemiology of the virus. These guidelines are designed to avoid the transmission of SARS-CoV-2 among both patients and healthcare staff as we gradually return to normal medical practice, to prevent postoperative complications and try to reduce possible deficiencies in the diagnosis, treatment and follow-up of the ophthalmic diseases. With this update (5th) the Spanish Society of Ophthalmology is placed as one of the major ophthalmology societies providing periodic and systematized recommendations for ophthalmic care during the COVID-19 pandemic

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Samples were collected in 9 regions. A pol fragment was amplified from plasma RNA or blood-extracted DNA. Phylogenetic analyses were performed via maximum likelihood, including database sequences of the same genetic forms as the identified clusters. Times and locations of the most recent common ancestors (MRCA) of clusters were estimated with a Bayesian method. Five large non-subtype B clusters associated with MSM were identified. The largest one, of F1 subtype, was reported previously. The other four were of CRF02_AG (CRF02_1; n = 115) and subtypes A1 (A1_1; n = 66), F1 (F1_3; n = 36), and C (C_7; n = 17). Most individuals belonging to them had been diagnosed of HIV-1 infection in the last 10 years. Each cluster comprised viruses from 3 to 8 Spanish regions and also comprised or was related to viruses from other countries: CRF02_1 comprised a Japanese subcluster and viruses from 8 other countries from Western Europe, Asia, and South America; A1_1 comprised viruses from Portugal, United Kingom, and United States, and was related to the A1 strain circulating in Greece, Albania and Cyprus; F1_3 was related to viruses from Romania; and C_7 comprised viruses from Portugal and was related to a virus from Mozambique. A subcluster within CRF02_1 was associated with heterosexual transmission. Near full-length genomes of each cluster were of uniform genetic form. Times of MRCAs of CRF02_1, A1_1, F1_3, and C_7 were estimated around 1986, 1989, 2013, and 1983, respectively. MRCA locations for CRF02_1 and A1_1 were uncertain (however initial expansions in Spain in Madrid and Vigo, respectively, were estimated) and were most probable in Bilbao, Spain, for F1_3 and Portugal for C_7. These results show that the HIV-1 epidemic among MSM in Spain is becoming increasingly diverse through the expansion of diverse non-subtype B clusters, comprising or related to viruses circulating in other countries

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines

APL'2002 Madrid Proceedings Automatic composition of music by means of Grammatical Evolution

This work describes how grammatical evolution may be applied to the domain of automatic composition. Our goal is to test this technique as an alternate tool for automatic composition. The AP440 auxiliary processor will be used to play music, thus we shall use a grammar that generates AP440 melodies. Grammar evolution will use fitness functions defined from several well-known single melodies to automatically generate AP440 compositions that are expected to sound like those compose

Preface to the volume Languages: Bionspired Approaches

This volume aims to provide a state-of-the-art of the work recently done, by some relevant Spanish Research Groups, in the area of nets of processors

The Spanish network on biomolecular and biocellular computing: bio-inspired natural computing in Spain

The Spanish Network on Biomolecular and Biocellular Computing (Redbiocom) is a consortium of seven Spanish research groups whose research activities focus on the bio-inspired approach to Natural Computing. The Network was founded in 2009 and it was funded by the Spanish Ministry of Science and Innovation under the Complementary Action TIN2008-04487-E/TIN.Pérez Jiménez, MDJ.; Ortega De La Puente, A.; Sempere Luna, JM. (2011). The Spanish network on biomolecular and biocellular computing: bio-inspired natural computing in Spain. Ercim News. 85:25-25. http://hdl.handle.net/10251/46690S25258